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EAAT1 antibody cytoplasmic domain - 250 116

EAATs are transmembrane proteins involved in the removal of extracellular glutamate
Chicken polyclonal IgY fraction
Cat. No.: 250 116
Amount: 200 µl
Price: $360.00
Cat. No. 250 116 200 µl antibody, lyophilized. Albumin and azide was added for stabilization. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 up to 1 : 2000 gallery  
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 522 to 541 from rat EAAT1 (UniProt Id: P24942)
Reactivity Reacts with: mouse (P56564), rat (P24942).
Other species not tested yet.
Matching control protein/peptide 250-11P
Data sheet 250_116.pdf
Cat. No.: 250 116
Amount: 200 µl
Price: $360.00
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. After the release of glutamate from synaptic vesicles into the synaptic cleft during neurotransmission, excitatory amino acid transporters (EAATs) remove extracellular glutamate to avoid excitotoxic levels.
Five EAATs with differential expression patterns have been described so far: EAAT 1, also referred to as GLAST and SLC1A3, has neuroprotective potential following ischemia and is expressed by reactive astrocytes and activated microglia. EAAT 2 (GLT-1, SLC1A2) is the most abundant and primarily expressed in astrocytes. EAAT 3 / SLC1A1 is expressed in neurons and has also been shown to be involved in the uptake of extracelluar cysteine. EAAT 4 shows weak expression in the forebrain and high levels in Purkinje cells of the cerebellum. EAAT 5 has only been described for humans and is primarily expressed in the retina.