| Cat. No. 351 011 |
100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: 1 : 500 gallery IHC: not tested yet IHC-P: not recommended FACS: yes |
| Clone | 10F7 |
| Subtype | IgG2a (κ light chain) |
| Immunogen | Recombinant protein corresponding to AA 26 to 601 from human CD31 (UniProt Id: P16284) |
| Reactivity |
Reacts with: human (P16284). Other species not tested yet. |
| Specificity | Recognizes all CD 31 isoforms. |
| Data sheet | 351_011.pdf |
CD31 or platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a cell adhesion molecule that contains a single trans-membrane domain and 6 Ig-like C2-type (immunoglobulin-like) domains (1). It is expressed on the surface of leukocytes and platelets and is primarily concentrated at endothelial cell-cell junctions (2). CD31 plays a role in several important biological processes, such as vascular development, maintenance of vascular endothelial barrier function and leukocyte emigration at inflammatory sites. In addition, CD31 promotes cancer metastasis by inducing epithelial-mesenchymal transition (3).