| Cat. No. 442 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 275 to 297 from mouse Chil3 (UniProt Id: O35744) |
| Reactivity |
Reacts with: mouse (O35744). Other species not tested yet. |
| Specificity | Specific for murine Chil3 / YM1, shows a cross-reactivity with Chil4 (Ym2) |
| Matching control protein/peptide | 442-0P |
| Data sheet | 442_004.pdf |
Chitinase-3-like protein 3, also referred to as Chil 3, Ym1 and ECF-L, is a secreted protein that is primarily produced by macrophages during inflammation. It is only expressed in rodents, but expression profile and domain organization suggest a functional overlap with human AMCase and SI-CLP. Chil 3 has chemotactic activity for eosinophils, T-cells and polymorphonuclear leukocytes, and plays a role in the inflammatory response elicited by parasitic infections, lung disorders and allergy.
This lectin binds chitin, heparin and GlcN oligomers. Although Chil 3 shares homology with chitinase family proteins, it has no enzymatic activity.