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CD 8a - HS-361 003

A T-cell surface glycoprotein
Polyclonal rabbit purified antibody
Cat. No.: HS-361 003
Amount: 200 µl
Price: 370.00 €
Cat. No. HS-361 003 200 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 200 µl H2O. Then aliquot and store at -20°C until use.
Applications IHC: 1 : 100 (see remarks) gallery  
IHC-P/FFPE: 1 : 100 gallery  
Immunogen Synthetic peptide corresponding to AA 230 to 247 from mouse CD8a (UniProt Id: P01731)
Reactivity Reacts with: mouse (P01731).
Other species not tested yet.
Specificity Specific for CD 8a.
Remarks

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical stainings.

Data sheet hs-361_003.pdf

References for CD 8a - HS-361 003

Common germline variants of the human APOE gene modulate melanoma progression and survival.
Ostendorf BN, Bilanovic J, Adaku N, Tafreshian KN, Tavora B, Vaughan RD, Tavazoie SF
Nature medicine (2020) : . HS-361 003 IHC; tested species: mouse
Loss of Setd4 delays radiation-induced thymic lymphoma in mice.
Feng X, Lu H, Yue J, Schneider N, Liu J, Denzin LK, Chan CS, De S, Shen Z
DNA repair (2020) 86: 102754. HS-361 003 IHC-P; tested species: mouse
Glioma escape signature and clonal development under immune pressure.
Maire CL, Mohme M, Bockmayr M, Fita KD, Riecken K, Börnigen D, Alawi M, Failla AV, Kolbe K, Zapf S, Holz M, et al.
The Journal of clinical investigation (2020) : . HS-361 003 IHC-P; tested species: mouse
Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model.
Linder B, Weirauch U, Ewe A, Uhmann A, Seifert V, Mittelbronn M, Harter PN, Aigner A, Kögel D
Cancers (2019) 113: . HS-361 003 IHC-P; tested species: mouse
Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy.
Kamran N, Kadiyala P, Saxena M, Candolfi M, Li Y, Moreno-Ayala MA, Raja N, Shah D, Lowenstein PR, Castro MG
Molecular therapy : the journal of the American Society of Gene Therapy (2017) 251: 232-248. HS-361 003 IHC-P
PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.
Wang J, Xie T, Wang B, William WN, Heymach JV, El-Naggar AK, Myers JN, Caulin C
Cancer prevention research (Philadelphia, Pa.) (2017) 1012: 684-693. HS-361 003 IHC-P
Cat. No.: HS-361 003
Quantity: 200 µl
Price: 370.00 €

CD8 positive T-cells in FFPE mouse spleen section

Common germline variants of the human APOE gene modulate melanoma progression and survival.
Ostendorf BN, Bilanovic J, Adaku N, Tafreshian KN, Tavora B, Vaughan RD, Tavazoie SF
Nature medicine (2020) : . HS-361 003 IHC; tested species: mouse
Loss of Setd4 delays radiation-induced thymic lymphoma in mice.
Feng X, Lu H, Yue J, Schneider N, Liu J, Denzin LK, Chan CS, De S, Shen Z
DNA repair (2020) 86: 102754. HS-361 003 IHC-P; tested species: mouse
Glioma escape signature and clonal development under immune pressure.
Maire CL, Mohme M, Bockmayr M, Fita KD, Riecken K, Börnigen D, Alawi M, Failla AV, Kolbe K, Zapf S, Holz M, et al.
The Journal of clinical investigation (2020) : . HS-361 003 IHC-P; tested species: mouse
Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model.
Linder B, Weirauch U, Ewe A, Uhmann A, Seifert V, Mittelbronn M, Harter PN, Aigner A, Kögel D
Cancers (2019) 113: . HS-361 003 IHC-P; tested species: mouse
Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy.
Kamran N, Kadiyala P, Saxena M, Candolfi M, Li Y, Moreno-Ayala MA, Raja N, Shah D, Lowenstein PR, Castro MG
Molecular therapy : the journal of the American Society of Gene Therapy (2017) 251: 232-248. HS-361 003 IHC-P
PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.
Wang J, Xie T, Wang B, William WN, Heymach JV, El-Naggar AK, Myers JN, Caulin C
Cancer prevention research (Philadelphia, Pa.) (2017) 1012: 684-693. HS-361 003 IHC-P
Background

CD 8 is a heterodimeric T-cell surface glycoprotein that consists of a CD 8a (alpha) and beta chain. It identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD 8 is thought to play a role in the process of T-cell mediated killing. CD 8 alpha chains binds to class I MHC molecules alpha-3 domains.

Protocols