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CD8a antibody mouse specific - HS-361 017

CD8a is a T-cell surface glycoprotein
Rat monoclonal purified IgG
Cat. No.: HS-361 017
Amount: 200 µl
Price: $415.00
Cat. No. HS-361 017 200 µl purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 200 µl H2O. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 (AP-staining) gallery  
IP: not tested yet
IHC: not tested yet
IHC-P: 1 : 100 gallery  
IHC-Fr: 1 : 200 (see remarks) gallery  
Clone GHH8/321E9
Subtype IgG2a
Immunogen Synthetic peptide corresponding to AA 230 to 247 from mouse CD8a (UniProt Id: P01731)
Reactivity Reacts with: mouse (P01731).
No signal: human, rat.
Other species not tested yet.
Remarks

IHC-Fr: PFA fixation is recommended.
Data sheet hs-361_017.pdf

References for CD8a - HS-361 017

Impact of Chemical-Induced Mutational Load Increase on Immune Checkpoint Therapy in Poorly Responsive Murine Tumors.
Kuczynski EA, Krueger J, Chow A, Xu P, Man S, Sundaravadanam Y, Miller JK, Krzyzanowski PM, Kerbel RS
Molecular cancer therapeutics (2018) 174: 869-882. HS-361 017 IHC-P; tested species: mouse
Helicobacter pylori γ-glutamyl transferase contributes to colonization and differential recruitment of T cells during persistence.
Wüstner S, Anderl F, Wanisch A, Sachs C, Steiger K, Nerlich A, Vieth M, Mejías-Luque R, Gerhard M
Scientific reports (2017) 71: 13636. HS-361 017 IHC-P; tested species: mouse
Cat. No.: HS-361 017
Amount: 200 µl
Price: $415.00

CD8 positive T-cells in FFPE mouse thymus section

Impact of Chemical-Induced Mutational Load Increase on Immune Checkpoint Therapy in Poorly Responsive Murine Tumors.
Kuczynski EA, Krueger J, Chow A, Xu P, Man S, Sundaravadanam Y, Miller JK, Krzyzanowski PM, Kerbel RS
Molecular cancer therapeutics (2018) 174: 869-882. HS-361 017 IHC-P; tested species: mouse
Helicobacter pylori γ-glutamyl transferase contributes to colonization and differential recruitment of T cells during persistence.
Wüstner S, Anderl F, Wanisch A, Sachs C, Steiger K, Nerlich A, Vieth M, Mejías-Luque R, Gerhard M
Scientific reports (2017) 71: 13636. HS-361 017 IHC-P; tested species: mouse
WB
IHC-P
IHC-P
IHC-Fr
Background

CD 8 is a heterodimeric T-cell surface glycoprotein that consists of a CD 8a (alpha) and beta chain. It identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD 8 is thought to play a role in the process of T-cell mediated killing. CD 8 alpha chains binds to class I MHC molecules alpha-3 domains.
Protocols for HS-361 017
WB
IHC-P
IHC-Fr
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