| Cat. No. HS-378 011 |
100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: 1 : 200 up to 1 : 1000 gallery |
| Clone | 37C12 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | Synthetic peptide corresponding to AA 832 to 847 from human Stat6 (UniProt Id: P42226) |
| Reactivity |
Reacts with: human (P42226). Other species not tested yet. |
| Data sheet | hs-378_011.pdf |
Nuclear STAT6 expression in hemangiopericytoma
STAT 6 (Signal Transducer and Activator of Transcription 6) is a member of the STAT family of transcription factors. Gene fusion of NGFI-A binding protein 2 (NAB 2) with STAT 6, which converts the transcriptional repressor NAB 2 into a transcriptional activator, was detected as driver mutation in solitary fibrous tumors (SFT). The NAB 2-STAT 6 fusion shows a consistent nuclear reallocation in STAT 6 immunohistochemistry. STAT 6 is a highly sensitive and specific immunohistochemical marker for most SFT and can be helpful to distinguish this tumor type from histologic mimics.
Although considered to be a distinct entity from meningeal SFT in the WHO Classification of CNS Tumours (2007), nuclear STAT 6 expression is additionally found in meningeal hemangiopericytoma (HPC). STAT 6 is a reliable marker to distinguish meningeal solitary fibrous tumors-hemangiopericytomas versus meningiomas.
This antibody is part of the HistoSure® product line, specifically developed and tested for human pathology.