|Cat. No. HS-391 017||
100 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: 1 : 200 up to 1 : 1000 gallery
|Subtype||IgG2a (κ light chain)|
|Immunogen||Synthetic peptide corresponding to C-terminal residues of mouse LAMP3. (UniProt Id: Q7TST5)|
Reacts with: mouse (Q7TST5), rat (Q5XI99), human (Q9UQV4).
Other species not tested yet.
|Specificity||Recognizes LAMP 3, no crossreactivity to LAMP 1, LAMP 2 and LAMP 5. K.O. validated|
LAMP3 / DC-LAMP positive mature dendritic cells in human squamous cell carcinoma lymph node metastasis
LAMP 3 (lysosome-associated membrane glycoprotein 3), also referred to as DC-LAMP (dendritic cell LAMP) or CD 208, is a member of the LAMP protein family and a single-pass type I transmembrane protein that can be variably glycosylated. It is specifically expressed in lung type II pneumocytes and by activated human dendritic cells (1, 2).
Recent studies demonstrated high expression of LAMP 3 in a variety of malignancies including squamous cell carcinoma, gastrointestinal cancer, breast cancer, ovarian cancer, and cervical cancer. Its expression has been associated with metastasis and poor overall survival (3, 4, 5).