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Ki67 - HS-398 102

A marker protein for proliferating cells
Polyclonal rabbit antiserum
Cat. No.: HS-398 102
Amount: 200 µl
Price: 350.00 €
Cat. No. HS-398 102 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications ICC: 1 : 1000 gallery  
IHC-P/FFPE: 1 : 2000 gallery  
Immunogen Synthetic peptide corresponding to AA 1234 to 1252 from mouse Ki67 (UniProt Id: E9PVX6)
Reactivity Reacts with: mouse (E9PVX6).
No signal: human (P46013), rat (D4A0Y6).
Other species not tested yet.
Specificity Specific for Ki 67
Data sheet hs-398_102.pdf
Cat. No.: HS-398 102
Quantity: 200 µl
Price: 350.00 €

Detection of proliferation antigen Ki-67 in FFPE mouse spleen section

Background

Expression of the nuclear protein Ki 67 is strictly associated with cell proliferation and preferentially expressed during the late G1, S, G2 and M phases of the cell cycle. Resting cells (G0 phase) lack Ki 67 expression .
Immunohistochemical detection of Ki 67 is a simple and reproducible method to determine the tumour proliferative index and is a predictive and prognostic biomarker in certain types of human cancer, such as breast cancer, gastric cancer or prostate cancer. Moreover, higher Ki 67 scores may be associated with increased tumor sensitivity to radiation therapy and chemotherapy.
In preclinical and clinical studies Ki 67 expression is used as a pharmacodynamic biomarker. Absence of a decrease in Ki 67 early in treatment might be predictive of therapeutic failure.

Protocols