|Cat. No. HS-439 003||200 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 200 µl H2O. Then aliquot and store at -20°C to -80°C until use.|
ICC: 1 : 1000 gallery
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 100 gallery
|Immunogen||Synthetic peptide corresponding to AA 527 to 547 from mouse CD19 (UniProt Id: P25918)|
Reacts with: mouse (P25918).
No signal: human (P15391), rat.
Other species not tested yet.
|Specificity||Specific for mouse CD19 without cross-reactivity to human and rat CD19.|
Indirect immunostaining of a formalin fixed paraffin-embedded mouse breast cancer model with rabbit anti-mouse CD19 (cat. no.: HS-439 003; DAB). Nuclei have been visualized by haematoxylin staining (blue).
CD19 (Cluster of Differentiation 19) is a B cell-restricted signal-transduction molecule that plays an important role in the regulation of development, activation, and differentiation of B-lymphocytes. CD19 is considered as a biomarker for B-cells because of its continued expression from very early B cell development stages. It is evident already on pro-B cells and on all later B cell stages, until plasma cell terminal differentiation, when its expression is lost. In complex with CD21, CD81 and CD225, CD19 functions as a dominant signaling receptor on the surface of mature B cells. CD19-deficient mice show defects in initial B-cell activation by T-cell-dependent antigens and in the maturation and/or selection of the activated cells into the memory compartment.