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CD19 antibody - HS-439 017

CD19 is a B-lymphocyte antigen
Rat monoclonal purified IgG
Cat. No.: HS-439 017
Amount: 100 µg
Price: $415.00
Cat. No. HS-439 017 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 250 gallery  
ICCgallery  
IHC: 1 : 200 gallery  
IHC-P/FFPE: 1 : 100 gallery  
Clone 26D7E5
Subtype IgG2b (κ light chain)
Epitop Epitop: AA 527 to 547 from mouse CD19 (UniProt Id: P25918)
Reactivity Reacts with: mouse (P25918).
No signal: human (P15391).
Other species not tested yet.
Specificity Specific for mouse CD19 without cross-reactivity to human CD19
Data sheet hs-439_017.pdf
Cat. No.: HS-439 017
Quantity: 100 µg
Price: $415.00

Chromogenic double staining for CD19 (DAB) and CD3e (RED) visualized T-cell and B-cell populations in the mouse spleen

Background

CD19 (Cluster of Differentiation 19) is a B cell-restricted signal-transduction molecule that plays an important role in the regulation of development, activation, and differentiation of B-lymphocytes. CD19 is considered as a biomarker for B-cells because of its continued expression from very early B cell development stages. It is evident already on pro-B cells and on all later B cell stages, until plasma cell terminal differentiation, when its expression is lost. In complex with CD21, CD81 and CD225, CD19 functions as a dominant signaling receptor on the surface of mature B cells. CD19-deficient mice show defects in initial B-cell activation by T-cell-dependent antigens and in the maturation and/or selection of the activated cells into the memory compartment.