CD19 antibody human specific - HS-439 103

B-lymphocyte antigen
Rabbit polyclonal purified antibody
Cat. No.: HS-439 103
Amount: 50 µg
Price: $370.00
Cat. No. HS-439 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
WB: 1 : 1000 gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P: 1 : 400 gallery  
Immunogen Synthetic peptide corresponding to AA 536 to 556 from human CD19 (UniProt Id: P15391)
Reactivity Reacts with: human (P15391).
No signal: mouse (P25918).
Other species not tested yet.
Data sheet hs-439_103.pdf
Cat. No.: HS-439 103
Amount: 50 µg
Price: $370.00

Immunohistochemical staining of B-cells in human spleen (left) but not in mouse spleen (right) using a human-specific anti-CD19 antibody.


CD19 (Cluster of Differentiation 19) is a B cell-restricted signal-transduction molecule that plays an important role in the regulation of development, activation, and differentiation of B-lymphocytes. CD19 is considered as a biomarker for B-cells because of its continued expression from very early B cell development stages, being evident already on pro-B cells and on all later B cell stages, until plasma cell terminal differentiation, when its expression is lost. In complex with CD21 (complement receptor-2), CD81 and CD225 (Leu-13), CD19 functions as a dominant signaling receptor on the surface of mature B cells (1). CD19 is instrumental in B cell homeostasis and lowers the threshold of B cell receptor crosslinking necessary to effect B-cell activation and sustain proliferation upon antigen encounter (2). Dysregulated CD19 expression has been implicated in several autoimmune diseases and CD19 is expressed in most acute lymphoblastic leukemias (ALL), chronic lymphocytic leukemias (CLL) and other B cell lymphomas (3). Therefore, CD19 has gained attention as a potential target in the therapy of B-cell malignancies (4).

Protocols for HS-439 103