| Cat. No. HS-442 117 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | SY-301F10 |
| Subtype | IgG2a (λ light chain) |
| Immunogen | Synthetic peptide corresponding to residues surrounding AA 280 of mouse Chil3 (UniProt Id: O35744) |
| Reactivity |
Reacts with: mouse (O35744). No signal: human. Other species not tested yet. |
| Specificity | Specific for mouse Chil3 / YM-1; no cross-reactivity with Chil4 / YM-2 |
| Data sheet | hs-442_117.pdf |
Chil3 / YM-1 expressing microglia and neutrophils in the inflamed mouse brain
Chitinase-3-like protein 3, also referred to as Chil 3, Ym1 and ECF-L, is a secreted protein that is primarily produced by macrophages during inflammation. It is only expressed in rodents, but expression profile and domain organization suggest a functional overlap with human AMCase and SI-CLP. Chil 3 has chemotactic activity for eosinophils, T-cells and polymorphonuclear leukocytes, and plays a role in the inflammatory response elicited by parasitic infections, lung disorders and allergy.
This lectin binds chitin, heparin and GlcN oligomers. Although Chil 3 shares homology with chitinase family proteins, it has no enzymatic activity.