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Nucleocapsid CoV-2 antibody - HS-452 011

CoV2 protein N packages the viral genome RNA
Monoclonal mouse purified IgG
Cat. No.: HS-452 011
Amount: 200 µl
Price: $415.00
Cat. No. HS-452 011 200 µl purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 200 µl H2O. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 gallery  
ICCgallery  
IHC: 1 : 1000 gallery  
IHC-P/FFPE: 1 : 1000 gallery  
ELISA: yes (see remarks) gallery  
Clone 4A8
Subtype IgG2b (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 419 from SARS-Cov-2 Nucleocapsid protein (UniProt Id: P0DTC9)
Epitop Epitop: AA 16 to 25 from SARS-Cov-2 Nucleocapsid protein (UniProt Id: P0DTC9)
Specificity Specific for SARS-CoV2
Remarks

ELISA: This antibody is suitable as capture antibody for sandwich-ELISA with cat. no. 452 111BT as detector antibody.

Data sheet hs-452_011.pdf
Cat. No.: HS-452 011
Quantity: 200 µl
Price: $415.00

Detection of SARS-CoV-2 nucleocapsid protein in brains of SARS-CoV-2 infected and non-infected K18-hACE2 transgenic mice.

Background

The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV2) is an enveloped positive-sense single stranded RNA virus that has been identified in the beginning of 2020 (1). It infects human host cells by docking via its spike protein (S) to the ACE2 surface receptor (2) and can cause mild to very severe and even deadly Covid-19 courses (3).
The very abundant Nucleocapsid or N-protein packages the viral RNA (4) and shares only little homology to other abundant members of the coronavirus family like NL63, 229E, HKU1 or OC43. This characteristic makes it a suitable target to discriminate between Covid-19 and other Coronavirus infections.