CD163 antibody human specific - HS-455 013

The scavenger receptor CD163 is a marker of cells from the monocyte / macrophage lineage
Rabbit polyclonal purified antibody
Cat. No.: HS-455 013
Amount: 50 µg
Price: $370.00
Cat. No. HS-455 013 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P: 1 : 400 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of human CD163 (UniProt Id: Q86VB7)
Reactivity Reacts with: human (Q86VB7).
No signal: mouse (Q2VLH6), rat.
Other species not tested yet.
Data sheet hs-455_013.pdf
Cat. No.: HS-455 013
Amount: 50 µg
Price: $370.00

Rabbit anti-human CD163 stains only CD163-positive cells in human liver. It does no stain CD163 in murine CD163-positive cells in mouse liver.


CD163 is a member of the group B scavenger receptor cysteine-rich (SRCR) superfamily expressed on human and murine macrophages. CD163 is also expressed in human monocytes, but not in circulating mouse monocytes (1). CD163 expression is significantly induced by anti-inflammatory stimuli like glucocorticoids and dexamethasone. Inflammatory stimuli like interferon γ and LPS suppress CD163 expression in macrophages (2). In mice, CD163 is mainly expressed by tissue-resident macrophages including Kupffer cells of the liver, red pulp macrophages in the spleen, perivascular macrophages of the CNS (3), and bone-marrow resident macrophages (4), but not by classical bone-marrow derived macrophages (4). In malignant tumors in mice and humans, macrophage CD163-mediated induction of IL-6 promotes tumor development and progression (4). The pool of tumor-associated macrophages (TAMs) is composed of both newly recruited monocyte derived macrophages and resident macrophages (5). CD163-positive tissue-resident macrophages have been shown to play a specific role in the malignant spread of disseminated tumor cells and the development of invasive disease in a mouse model of metastatic ovarian cancer (1). CD163 is considered useful to distinguish CD163-positive resident macrophages from CD163-negative bone-marrow derived macrophages in mice (4).

Protocols for HS-455 013