|Cat. No. HS-488 003||
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IHC: 1 : 500 gallery
Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: 1 : 1000 up to 1 : 2000 gallery
|Immunogen||Synthetic peptide corresponding to residues near the carboxy terminus of mouse CD206 (UniProt Id: Q61830)|
Reacts with: mouse (Q61830), rat, human (P22897).
Other species not tested yet.
Tumor-Associated mouse macrophages express CD206 (brown) and F4/80 (red)
CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a member of the C-type lectin (CLEC) family. CD206 is expressed by subpopulations of macrophages, immature dendritic cells, and liver sinusoidal endothelial cells. Its expression level is differentially regulated by cytokines (e.g., IL-10, IL-4, IL-13, and IFNγ), prostaglandins, LPS, and the transcription factor PPAR-γ (1). CD206 functions in endocytosis and phagocytosis (1) and high expression is found both on pro- and antitumor TAMs (tumor-associated macrophages) (2). In the brain, border-associated macrophages (BAMs) can be discriminated from microglia by the expression of CD206 and CD169 (3).