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Aquaporin4 antibody - 429 006

Aquaporin4 is a water-specific channel in the blood brain barrier
Chicken polyclonal purified antibody
Cat. No.: 429 006
Amount: 50 µg
Price: $380.00
Cat. No. 429 006 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 1000 up to 1 : 2000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 249 to 323 from mouse Aquaporin-4 isoform 2 (UniProt Id: P55088-1)
Reactivity Reacts with: rat (P47863), mouse (P55088-1).
Other species not tested yet.
Specificity Specific for Aquaporin-4, detects all described isoforms.
Matching control protein/peptide 429-0P
Data sheet 429_006.pdf

References for Aquaporin4 - 429 006

Inhibiting astrocyte connexin-43 hemichannels blocks radiation-induced vesicular VEGF-A release and blood-brain barrier dysfunction.
Schumacher S, Tahiri H, Ezan P, Rouach N, Witschas K, Leybaert L
Glia (2024) 721: 34-50. 429 006 IHC; tested species: mouse
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Choi BJ, Park MH, Park KH, Han WH, Yoon HJ, Jung HY, Hong JY, Chowdhury MR, Kim KY, Lee J, Song IS, et al.
Nature communications (2023) 141: 1631. 429 006 IHC; tested species: mouse
Evaluation of gliovascular functions of Aqp4 readthrough isoforms.
Mueller SM, White KM, Fass SB, Chen S, Shi Z, Ge X, Engelbach JA, Gaines SH, Bice AR, Vasek MJ, Garbow JR, et al.
bioRxiv : the preprint server for biology (2023) : . 429 006 IHC; tested species: mouse
Cat. No.: 429 006
Amount: 50 µg
Price: $380.00
Inhibiting astrocyte connexin-43 hemichannels blocks radiation-induced vesicular VEGF-A release and blood-brain barrier dysfunction.
Schumacher S, Tahiri H, Ezan P, Rouach N, Witschas K, Leybaert L
Glia (2024) 721: 34-50. 429 006 IHC; tested species: mouse
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Choi BJ, Park MH, Park KH, Han WH, Yoon HJ, Jung HY, Hong JY, Chowdhury MR, Kim KY, Lee J, Song IS, et al.
Nature communications (2023) 141: 1631. 429 006 IHC; tested species: mouse
Evaluation of gliovascular functions of Aqp4 readthrough isoforms.
Mueller SM, White KM, Fass SB, Chen S, Shi Z, Ge X, Engelbach JA, Gaines SH, Bice AR, Vasek MJ, Garbow JR, et al.
bioRxiv : the preprint server for biology (2023) : . 429 006 IHC; tested species: mouse
ICC
ICC
IHC
IHC
IHC
Background

Aquaporin4, or AQP4, also known as Mercurial-insensitive water channel (MIWC), is a member of the aquaporin water channel family. This osmoreceptor regulates body water balance and mediates water flow within the central nervous system.
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