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CD 11c - HS-375 003

A fibrinogen receptor involved in cell-cell interaction during inflammation
Polyclonal rabbit purified antibody
Cat. No.: HS-375 003
Amount: 200 µl
Price: 370.00 €
Cat. No. HS-375 003 200 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 200 µl H2O. Then aliquot and store at -20°C until use.
Applications IHC: 1 : 100 (see remarks) gallery  
IHC-P/FFPE: 1 : 100 gallery  
Immunogen Synthetic peptide corresponding to AA 1159 to 1169 from mouse CD11c (UniProt Id: Q9QXH4)
Reactivity Reacts with: mouse (Q9QXH4).
No signal: rat, human (P20702).
Other species not tested yet.
Specificity Specific for CD 11c.
Remarks

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical stainings

Data sheet hs-375_003.pdf

References for CD 11c - HS-375 003

STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. HS-375 003 IHC; tested species: mouse
Cat. No.: HS-375 003
Quantity: 200 µl
Price: 370.00 €

CD11c positive cells in FFPE mouse spleen section

STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI.
Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, et al.
Brain, behavior, and immunity (2019) 81: 228-246. HS-375 003 IHC; tested species: mouse
Background
CD 11c or Integrin alpha-X (ITGAX) is a heterodimeric glycoprotein consisting of an α- and β-subunit and has seven repeating integrin domains. This transmembrane receptor type I plays a pivotal role in T cell killing and mediates intercellular adhesions during inflammation. Predominat expression levels have been found in dendritic cells, monocytes, macrophages, neutrophils and a small subset of B cells. Under pathological conditions, CD 11c is a marker for hairy cell leukemia, acute non-lymphocytic leukemias, and some chronic lymphocytic leukemias.
Protocols