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CD 11c - HS-375 003

A fibrinogen receptor involved in cell-cell interaction during inflammation
Polyclonal rabbit purified antibody
Cat. No.: HS-375 003
Amount: 200 µl
Price: 370.00 €
Cat. No. HS-375 003  200 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 200 µl H2O. Then aliquot and store at -20°C until use.
Applications IHC: 1 : 100 (see remarks) gallery  
IHC-P/FFPE: 1 : 100 gallery  
Immunogen Synthetic peptide corresponding to AA 1159 to 1169 from mouse CD11c (UniProt Id: Q9QXH4)
Reactivity Reacts with: mouse (Q9QXH4).
No signal: rat, human (P20702).
Other species not tested yet.
Specificity Specific for CD 11c.
Remarks

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical stainings

Data sheet hs-375_003_.pdf
Cat. No.: HS-375 003
Quantity: 200 µl
Price: 370.00 €

CD11c positive cells in FFPE mouse spleen section

Background
CD 11c or Integrin alpha-X (ITGAX) is a heterodimeric glycoprotein consisting of an α- and β-subunit and has seven repeating integrin domains. This transmembrane receptor type I plays a pivotal role in T cell killing and mediates intercellular adhesions during inflammation. Predominat expression levels have been found in dendritic cells, monocytes, macrophages, neutrophils and a small subset of B cells. Under pathological conditions, CD 11c is a marker for hairy cell leukemia, acute non-lymphocytic leukemias, and some chronic lymphocytic leukemias.
Protocols