Cat. No. HS-375 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
Applications | |
Immunogen | Synthetic peptide corresponding to AA 1159 to 1169 from mouse CD11c (UniProt Id: Q9QXH4) |
Reactivity |
Reacts with: mouse (Q9QXH4). No signal: human (P20702), rat (D3ZWZ1). Other species not tested yet. |
Matching control protein/peptide | 375-0P |
Data sheet | hs-375_004.pdf |
CD11c positive cells in FFPE mouse spleen section
CD11c or Integrin alpha-X (ITGAX) is a heterodimeric glycoprotein consisting of an α- and β-subunit and has seven repeating integrin domains. This transmembrane receptor type I plays a pivotal role in T cell killing and mediates intercellular adhesions during inflammation. Predominat expression levels have been found in dendritic cells, monocytes, macrophages, neutrophils and a small subset of B cells. Under pathological conditions, CD11c is a marker for hairy cell leukemia, acute non-lymphocytic leukemias, and some chronic lymphocytic leukemias.