Mouse Tissue-Resident Macrophages


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Tissue-resident macrophages (TRMs) have specialized functions based on their locations and distinct gene expression profiles. They have been implicated in tissue development (e.g. bone formation, brain development, mammary gland development), tissue homeostasis (e.g. maintenance of insulin sensitivity, thermogenic gene induction, hepatic lipid homeostasis) and the resolution of inflammation. In contrast, recruited monocytes - that become macrophages in tissues - are viewed as key players during inflammation and pathogen challenge.

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