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IBA 1 - HS-234 004

A calcium binding protein specific for microglia
Polyclonal Guinea pig antiserum
Cat. No.: HS-234 004
Amount: 100 µl
Price: 350.00 €
Cat. No. HS-234 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 134 to 147 from rat IBA1 (UniProt Id: P55009)
Reactivity Reacts with: mouse (Q9EQW9), rat (P55009), human (P55008).
Other species not tested yet.
Specificity Specific for IBA 1.
Data sheet hs-234_004.pdf

References for IBA 1 - HS-234 004

Treatment of rats with spinal cord injury using human bone marrow-derived stromal cells prepared by negative selection.
Romero-Ramírez L, Wu S, de Munter J, Wolters EC, Kramer BW, Mey J
Journal of biomedical science (2020) 271: 35. HS-234 004 IHC-P; tested species: rat
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . HS-234 004 IHC-P; tested species: mouse
Cat. No.: HS-234 004
Quantity: 100 µl
Price: 350.00 €

IBA 1 positive cells in FFPE mouse thymus section

Treatment of rats with spinal cord injury using human bone marrow-derived stromal cells prepared by negative selection.
Romero-Ramírez L, Wu S, de Munter J, Wolters EC, Kramer BW, Mey J
Journal of biomedical science (2020) 271: 35. HS-234 004 IHC-P; tested species: rat
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, et al.
Acta neuropathologica (2018) : . HS-234 004 IHC-P; tested species: mouse
Background

Ionized calcium-binding adaptor molecule 1 (IBA1) or allograft inflammatory factor1 (AIF-1) is an EF hand calcium binding protein which is expressed by cells of the monocyte/macrophage lineage and by germ cells in the testis (1). In mice, IBA1/AIF-1 can be regarded a “pan-macrophage marker” because, except for alveolar macrophages, all subpopulations of macrophages express IBA1/AIF-1 (1). In human gliomas IBA1 defines a distinct subset of tumor-associated activated macrophages/microglial cells (2).
Microglia represent the resident macrophages in the nervous system and are the smallest of the glial cells with cell bodies of only 2-5 µm in diameter. In the CNS IBA1 upregulation is associated with neuroinflammatory response (3). 

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