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CD11c antibody - HS-375 017

CD11c is a fibrinogen receptor involved in cell-cell interaction during inflammation
Rat monoclonal purified IgG
Cat. No.: HS-375 017
Amount: 100 µg
Price: $415.00
Cat. No. HS-375 017 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 100 gallery  
IHC-Fr: 1 : 500 (see remarks) gallery  
Clone SY-322C12
Subtype IgG2b (κ light chain)
Immunogen synthetic peptide corresponding to residues surrounding AA 847 of mouse CD11c (UniProt Id: Q9QXH4)
Reactivity Reacts with: mouse (Q9QXH4).
No signal: rat, human (P20702).
Other species not tested yet.
Specificity Specific for mouse CD11c without cross-reactivity to human CD11c
Remarks

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical stainings
IHC-Fr: PFA fixation is recommended.

Data sheet hs-375_017.pdf
Cat. No.: HS-375 017
Amount: 100 µg
Price: $415.00

CD11c positive cells in FFPE mouse ileum section

Background
CD 11c or Integrin alpha-X (ITGAX) is a heterodimeric glycoprotein consisting of an α- and β-subunit and has seven repeating integrin domains. This transmembrane receptor type I plays a pivotal role in T cell killing and mediates intercellular adhesions during inflammation. Predominat expression levels have been found in dendritic cells, monocytes, macrophages, neutrophils and a small subset of B cells. Under pathological conditions, CD 11c is a marker for hairy cell leukemia, acute non-lymphocytic leukemias, and some chronic lymphocytic leukemias.